Diabetic nephropathy (DN) has been identified as the major cause of end-stage renal disease (ESRD) in most developed countries.MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F transcription factor 3 (E2F3) could facilitate podocyte injury.Nevertheless, whether E2F3 is involved in
Abstract Background Consideration of tissue-specific gene expression in reconstruction and analysis of molecular genetic networks is necessary for a proper CD description of the processes occurring in a specified tissue.Currently, there are a number of computer systems that allow the user to reconstruct molecular-genetic networks using the data aut
There is a growing evidence that social determinants of health influence the health outcomes.These non-medical factors, i.e., social determinants of health / mental health, are defined as the conditions in which people are born, grow, live, work and age, including the factors shaping these conditions.They either have direct effects on health and il
Flow through open channels can contain solids.The deposition of solids occasionally occurs due to insufficient flow velocity to transfer the solid particles, causing many problems with transfer systems.Therefore, a method to determine the limiting velocity (i.e.Fr) is required.In Kitchen this paper, three alternative, hybrid evolutionary algorithm
In this work, a new constrained numerical optimization approach is proposed for solving offline the Inverse Kinematics Problem (IKP) of articulated robots, which consists on optimizing the joint displacement while the end effector is positioned and oriented in a desired pose.The novelty of this approach is in the formulation of the optimization pro